Knobelsdorff is a surname. Notable people with the surname include:
Alexander von Knobelsdorff (1723–1799), Prussian general of the War of the First Coalition Elisabeth von Knobelsdorff (1877–1959), German engineer and architect Georg Wenzeslaus von Knobelsdorff (1699–1753), Prussian painter and architect Konstantin Schmidt von Knobelsdorf (1860–1936), German general and chief-of-staff of World War I Otto von Knobelsdorff (1886–1966), German panzer general of World War II Manfred von Knobelsdorff (1892–1965), SS officer