DM1 can refer to
Diabetes mellitus type 1 A form of Myotonic dystrophy Myotonin-protein kinase, that is, dystrophia myotonica 1 or dystrophia myotonica protein kinase, a ubiquitous protein whose abnormal expression is associated with myotonic dystrophy in ways not yet well understood Mertansine, a maytansinoid cytotoxic agent used in trastuzumab emtansine and other antibody-drug conjugates The Lippisch DM-1 a German delta wing research glider An office based variant of the ICL Series 39 mainframe manufactured by International Computers Limited (ICL) in the 1980s SpaceX DM1, an orbital test of Dragon 2 spacecraft DM-1, one of the designations carried by a US Navy destroyer