GTP diphosphokinase

GTP diphosphokinase () is an enzyme that catalyzes the chemical reaction

The enzyme characterised from species of Bacillus converts guanosine triphosphate (GTP) to guanosine 3'-diphosphate 5'-triphosphate by transferring a pyrophosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine monophosphate (AMP).

Nomenclature This enzyme is a transferase, specifically one transferring two phosphorus-containing groups (diphosphotransferases). The systematic name of this enzyme class is ATP:GTP 3'-diphosphotransferase. Other names in common use include stringent factor, guanosine 3',5'-polyphosphate synthase, GTP pyrophosphokinase, ATP-GTP 3'-diphosphotransferase, guanosine 5',3'-polyphosphate synthetase, (p)ppGpp synthetase I, (p)ppGpp synthetase II, guanosine pentaphosphate synthetase, GPSI, and GPSII.

Structural studies As of late 2007, 4 structures have been solved for this class of enzymes, with Protein Data Bank accession codes , , , and .

References