Deoxyguanosine kinase () is an enzyme that catalyzes a chemical reaction that transfers a phosphate group from the cofactor, adenosine triphosphate (ATP), to deoxyguanosine. This gives adenosine diphosphate (ADP) and deoxyguanosine monophosphate:
The enzyme has ben found in calf thymus and mouse.
This enzyme is a transferase, specifically one transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:deoxyguanosine 5'-phosphotransferase. Other names in common use include deoxyguanosine kinase (phosphorylating), (dihydroxypropoxymethyl)guanine kinase, 2'-deoxyguanosine kinase, and NTP-deoxyguanosine 5'-phosphotransferase.
Structural studies As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes , , , and .
Clinical Mutations in this gene have been linked to inherited mitochondrial DNA depletion syndromes, neonatal liver failure, nystagmus and hypotonia.
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