3-deoxy-manno-octulosonate cytidylyltransferase () is an enzyme that catalyzes the chemical reaction
The enzyme characterised from Escherichia coli combines 3-deoxy-D-manno-oct-2-ulosonic acid and cytidine triphosphate to give CMP-3-deoxy-β-D-manno-octulosonic acid, with pyrophosphate (PPi) as a byproduct. The reaction is part of the biosynthesis of lipopolysaccharide.
This enzyme is a transferases, specifically one transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:3-deoxy-D-manno-octulosonate cytidylyltransferase. Other names in common use include CMP-3-deoxy-D-manno-octulosonate pyrophosphorylase, 2-keto-3-deoxyoctonate cytidylyltransferase, 3-Deoxy-D-manno-octulosonate cytidylyltransferase, CMP-3-deoxy-D-manno-octulosonate synthetase, CMP-KDO synthetase, CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase, and cytidine monophospho-3-deoxy-D-manno-octulosonate pyrophosphorylase.
Structural studies As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , , , , and .
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