Diiodotyrosine transaminase () is an enzyme that catalyzes the reversible chemical reaction
The two substrates of this enzyme characterised from rat kidney are diiodotyrosine and α-ketoglutaric acid. Its products are 3,5-diiodo-4-hydroxyphenyl)pyruvic acid (1) and L-glutamic acid. It uses pyridoxal phosphate as a cofactor and is involved in the breakdown of thyroid hormones.
This enzyme is a transferase, specifically a transaminase, which transfer nitrogenous groups. The systematic name of this enzyme class is 3,5-diiodo-L-tyrosine:2-oxoglutarate aminotransferase. Other names in common use include diiodotyrosine aminotransferase, halogenated tyrosine aminotransferase, and halogenated tyrosine transaminase.
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