Glycine N-acyltransferase (GLYAT), also known as acyl-CoA:glycine N-acyltransferase (ACGNAT), () is an enzyme that catalyzes a general chemical reaction in which glycine is converted to an N-acyl derivative.
For example, glycine reacts with benzoyl-CoA to give hippuric acid:
Benzoic acid is metabolized by butyrate-CoA ligase into the intermediate, benzoyl-CoA, which is then metabolized by glycine N-acyltransferase into hippuric acid.
The enzyme is a transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:glycine N-acyltransferase. Other names in common use include glycine acyltransferase, and glycine-N-acylase.
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