Benzophenone synthase () is an enzyme that catalyzes a chemical reaction which takes one unit of 3-hydroxybenzoyl-CoA and combines this with three units of malonyl-CoA to give the benzophenone, 2,3',4,6-tetrahydroxybenzophenone, as product. Four units of coenzyme A and three of carbon dioxide are byproducts. The enzyme was characterised from the plant Centaurium erythraea. The product is an intermediate in the biosynthesis of xanthones.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:3-hydroxybenzoyl-CoA malonyltransferase.
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