2-hydroxyglutarate synthase () is an enzyme that catalyzes the chemical reaction
The three substrates of this enzyme are glyoxylic acid, propanoyl-CoA, and water. Its products are α-hydroxyglutaric acid and coenzyme A.
This enzyme belongs to the family of transferases, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer. The systematic name of this enzyme class is propanoyl-CoA:glyoxylate C-propanoyltransferase (thioester-hydrolysing, 2-carboxyethyl-forming). Other names in common use include 2-hydroxyglutaratic synthetase, 2-hydroxyglutaric synthetase, alpha-hydroxyglutarate synthase, hydroxyglutarate synthase, and 2-hydroxyglutarate glyoxylate-lyase (CoA-propanoylating).
See also D2HGDH L2HGDH 2-hydroxyglutarate dehydrogenase 2-Hydroxyglutaric aciduria Hydroxyacid-oxoacid transhydrogenase
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