N-acetylglucosamine deacetylase () is an enzyme that catalyzes the chemical reaction
The enzyme characterised from Escherichia coli hydrolyses N-acetylglucosamine to glucosamine and acetic acid. It has also been found in Acinetobacter baumannii. The enzyme has been studied as a means of manufacturing glucosamine.
This enzyme belongs is a hydrolase, one acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-acetyl-D-glucosamine amidohydrolase. Other names in use include acetylaminodeoxyglucose acetylhydrolase, and N-acetyl-D-glucosaminyl N-deacetylase.
Structural studies As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .
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