Acyl-lysine deacylase () is an enzyme that catalyzes the general chemical reaction in which an acyl group is removed from the amino acid, L-lysine, by hydrolysis:
N6-acyl-L-lysine + H2O a carboxylate + L-lysine
For example, the enzyme characterised from rat kidney converts acetyllysine to lysine and acetic acid:
In some cases, the lysine is incorporated in proteins and the enzyme class is called the sirtuins, a type of protein deacetylase.
This enzyme is a hydrolase, one acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N6-acyl-L-lysine amidohydrolase. Other names in common use include epsilon-lysine acylase, and 6-N-acyl-L-lysine amidohydrolase.
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