Uridine nucleosidase () is an enzyme that catalyzes the chemical reaction

The enzyme characterised from yeast hydrolyses the pyrimidine nucleoside, uridine, to uracil and D-ribose. The enzyme is also found in plants.

This enzyme is a hydrolase, specifically a glycosylase that hydrolyses N-glycosyl compounds. The systematic name of this enzyme class is uridine ribohydrolase. This enzyme is also called uridine hydrolase.

Structural studies As of late 2007, 23 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , , , , , , , , , , , , , , , , and .

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