The enzyme cyclohexyl-isocyanide hydratase () catalyzes the chemical reaction

N-cyclohexylformamide cyclohexyl isocyanide + H2O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is N-cyclohexylformamide hydro-lyase (cyclohexyl-isocyanide-forming). Other names in common use include isonitrile hydratase, and ''N''-cyclohexylformamide hydro-lyase. This enzyme participates in caprolactam degradation.

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