Retinoic acid receptor gamma (RAR-γ), also known as NR1B3 (nuclear receptor subfamily 1, group B, member 3) is a nuclear receptor encoded by the RARG gene. Adapalene selectively targets retinoic acid receptor beta and retinoic acid receptor gamma and its agonism of the gamma subtype is largely responsible for adapalene's observed effects.
Interactions
Retinoic acid receptor gamma has been shown to interact with NCOR1.
Ligands Agonists Adapalene (also agonist at RARβ and weakly at RARα) CD1530Yimiti D, Uchibe K, Toriyama M, Hayashi Y, Ikuta Y, Nakasa T, Akiyama H, Watanabe H, Kondoh G, Takimoto A, Shukunami C, Adachi N, Miyaki S. CD1530, selective RARγ agonist, facilitates Achilles tendon healing by modulating the healing environment including less chondrification in a mouse model. J Orthop Res. 2025 Feb;43(2):273-284. Tazarotene (mixed RARβ/RARγ agonist, selective over RARα) Trifarotene (RARγ selective)
Antagonists LY2955303Hughes NE, Bleisch TJ, Jones SA, Richardson TI, Doti RA, Wang Y, Stout SL, Durst GL, Chambers MG, Oskins JL, Lin C, Adams LA, Page TJ, Barr RJ, Zink RW, Osborne H, Montrose-Rafizadeh C, Norman BH. Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design. Bioorg Med Chem Lett. 2016 Jul 15;26(14):3274-3277. MM11253Holmes WF, Dawson MI, Soprano RD, Soprano KJ. Induction of apoptosis in ovarian carcinoma cells by AHPN/CD437 is mediated by retinoic acid receptors. J Cell Physiol. 2000 Oct;185(1):61-7.
See also Retinoic acid receptor
References
Further reading