As a surname, "Goodspeed" derives from "Godspeed", which in turn comes from the expression "God speed (you)", a wish for success and fortune on behalf of one setting out on a trip or an enterprise.

People with the surname Dan Goodspeed (born 1977), US athlete in football Edgar J. Goodspeed (1871–1962), US theologian, scholar and author of numerous writings about the Bible Estella Goodspeed and Allen Goodspeed, wife and son of Arthur Scott Bailey Joey Goodspeed (born 1978), US athlete in football Marjorie Reynolds (1917–1997), US film actress, born Marjorie Goodspeed Paula Goodspeed (born 1978), US singer and American Idol auditioner, accused stalker of Paula Abdul Tyler Goodspeed (born 1984/85), American economist

In fiction Ethan Rom, alias of Dr. Ethan Goodspeed, a character in the US television series Lost Gary Goodspeed, the main character of the US animated television series Final Space Horace Goodspeed, a character in the US television series Lost Patience Goodspeed, the main character in The Voyage of Patience Goodspeed and The Education of Patience Goodspeed, by Heather Vogel Frederick Dr. Stanley Goodspeed, a character in the 1996 US film The Rock

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