In enzymology, a 2-oxoglutarate carboxylase () is an enzyme that catalyzes the chemical reaction
ATP + 2-oxoglutarate + HCO3- ADP + phosphate + oxalosuccinate
The 3 substrates of this enzyme are ATP, 2-oxoglutarate, and HCO3-, whereas its 3 products are ADP, phosphate, and oxalosuccinate.
This enzyme belongs to the family of ligases, specifically those forming carbon-carbon bonds. The systematic name of this enzyme class is '''. Other names in common use include oxalosuccinate synthetase, carboxylating factor for ICDH (incorrect), CFI, and OGC'''.
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