Phosphoribosylaminoimidazolecarboxamide formyltransferase (), also known by the shorter name AICAR transformylase, is an enzyme that catalyzes the chemical reaction
This tetrahydrofolate–dependent enzyme catalyzes a nucleophilic acyl substitution of the formyl group from the cofactor 10-formyltetrahydrofolate (10-CHO-THF) to AICA ribonucleotide to give 5-formamidoimidazole-4-carboxamide ribotide (FAICAR). This reaction is involved in purine metabolism.
Nomenclature This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 10-formyltetrahydrofolate:5-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase. Other names in common use include:
10-formyltetrahydrofolate:5-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase 5-amino-1-ribosyl-4-imidazolecarboxamide 5-phosphate, 5-amino-4-imidazolecarboxamide ribonucleotide transformylase, 5-amino-4-imidazolecarboxamide ribotide transformylase, 5-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase, AICAR formyltransferase, AICAR transformylase, aminoimidazolecarboxamide ribonucleotide transformylase, and transformylase, bifunctional purine biosynthesis protein PURH, ATIC.
Structural studies As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , , , , and .
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