Mangano is an Italian surname. Notable people with the surname include:
Anthony Mangano, American actor Ed Mangano (born 1962), American politician from New York Guy James Mangano (1930–2025), American politician and jurist from New York Joy Mangano (born 1956), American inventor Lawrence Mangano (1892–1944), American mobster Philip Mangano (1898–1951), American mafioso Silvana Mangano (1930–1989), Italian actress Venero Mangano (1921–2017), American mafioso Vincent Mangano (1888–1951), American mafioso Vittorio Mangano (1940–2000), Italian member of Cosa Nostra
See also Maingano, a fish in the family Cichlidae, scientific name Melanochromis cyaneorhabdos