In enzymology, glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) () is an enzyme that catalyzes the chemical reaction
The three substrates of this enzyme are D-glyceraldehyde 3-phosphate, phosphate (Pi), and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are 1,3-bisphosphoglyceric acid, reduced NADH, and a proton. The enzyme can use nicotinamide adenine dinucleotide phosphate as an alternative cofactor.P. Mathis (Ed.), Photosynthesis: From Light to Biosphere, vol. 1, Kluwer Academic Publishers, 1995, p. 959-962
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of a donor with NAD+ or NADP+ as an acceptor. The systematic name of this enzyme class is D-glyceraldehyde 3-phosphate:NAD(P)+ oxidoreductase (phosphorylating). Other names in common use include triosephosphate dehydrogenase (NAD(P)) (phosphorylating), and glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating).
Structural studies As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .
See also Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) which catalyses the same reaction
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