Integrin alpha V

Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene.

Function

ITGAV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; ITGB1, ITGB3, ITGB5, ITGB6, and ITGB8), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.

Alpha V class integrins In mammals the integrins that include alpha-V are :

Name Synonyms Distribution Ligands αVβ1 neurological tumors vitronectin; fibrinogen αVβ3 vitronectin receptor activated endothelial cells, melanoma, glioblastoma vitronectin, fibronectin, fibrinogen, osteopontin, Cyr61, thyroxine αVβ5 widespread, esp. fibroblasts, epithelial cells vitronectin and adenovirus αVβ6 proliferating epithelia, esp. lung and mammary gland fibronectin; TGFβ1+3 αVβ8 neural tissue; peripheral nerve fibronectin; TGFβ1+3

Clinical significance Overexpression of the ITGAV gene is associated with progression and spread of colorectal cancer, and prostate cancer.

As a drug target The mAbs intetumumab, and abituzumab target this protein which is found on some tumour cells.

Integrin alpha V

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