No Laughing Matter may refer to:
No Laughing Matter (book), an autobiographical work by Joseph Heller about his Guillain–Barré syndrome "No Laughing Matter", an episode from season nine of the M*A*S*H TV series "No Laughing Matter" (Garfield and Friends), an episode from the second season of Garfield and Friends "No Laughing Matter", a season 2 episode of The Loud House