Androst-4-ene-3,17-dione monooxygenase () is an enzyme that catalyzes the chemical reaction
The three substrates of this enzyme are the steroid hormone, androstenedione, a reduced electron acceptor, and oxygen. Its products are testololactone, the electron acceptor, and water.
This enzyme is an oxidoreductase that uses molecular oxygen to carry out a Baeyer–Villiger oxidation. The systematic name of this enzyme class is androst-4-ene-3,17-dione-hydrogen-donor:oxygen oxidorcockeductase (13-hydroxylating, lactonizing). Other names in common use include androstene-3,17-dione hydroxylase, androst-4-ene-3,17-dione 17-oxidoreductase, androst-4-ene-3,17-dione hydroxylase, androstenedione monooxygenase, and 4-androstene-3,17-dione monooxygenase.
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