Methylquercetagetin 6-O-methyltransferase () is an enzyme that catalyzes the chemical reaction

This is a methylation reaction in which the O-methylated flavonoid, tomentin (methylquercetagetin), is converted to chrysosplenol D. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). These compounds are found in Chrysosplenium americanum

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone 6-O-methyltransferase. Other names in common use include flavonol 6-O-methyltransferase, flavonol 6-methyltransferase, 6-OMT, S-adenosyl-L-methionine:3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone, and 6-O-methyltransferase.

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