Caffeate O-methyltransferase () is an enzyme that catalyzes the chemical reaction
This is a methylation reaction in which caffeic acid is converted to ferulic acid. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH).
The enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase. Other names in common use include caffeate methyltransferase, caffeate 3-O-methyltransferase, and ''S-adenosyl-L-methionine:caffeic acid-O''-methyltransferase. This enzyme participates in phenylpropanoid biosynthesis.
Structural studies As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .
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