Route 253 or Highway 253 may refer to:
Canada Nova Scotia Route 253 Quebec Route 253
Costa Rica National Route 253
Japan Japan National Route 253
Korea, South Gochang–Damyang Expressway
United Kingdom road B253 road
United States Alabama State Route 253 Arkansas Highway 253 California State Route 253 Georgia State Route 253 Iowa Highway 253 (former) K-253 (Kansas highway) Kentucky Route 253 Maryland Route 253 Minnesota State Highway 253 Montana Secondary Highway 253 New Mexico State Road 253 New York State Route 253 Ohio State Route 253 Pennsylvania Route 253 South Carolina Highway 253 South Dakota Highway 253 Tennessee State Route 253 Texas State Highway 253 (former) Farm to Market Road 253 (Texas) Utah State Route 253 (former) Vermont Route 253 Virginia State Route 253 Wisconsin Highway 253 Wyoming Highway 253 Territories Puerto Rico Highway 253