Túpac Amaru (1545–1572) was the last indigenous leader of the Inca empire.

Túpac Amaru may also refer to: Túpac Amaru II (1742–1781), Peruvian leader of an indigenous uprising Diego Cristóbal Túpac Amaru (1750–1783), succeeded Túpac Amaru II as the uprising's leader Andrés Túpac Amaru (1763–1786), nephew of Túpac Amaru II, fought in the uprising Túpac Amaru Revolutionary Movement, a Peruvian communist guerrilla group Tupac Amaru Hunter (born 1973), U.S. politician Tupac Amaru Shakur (1971–1996), American rapper

See also Tupamaros, a Uruguayan communist guerrilla group Tupamaro (Venezuela), a political party of Venezuela until 2007 Tupac (name), a given name (and list of people with that name)