Mississippi was admitted to the Union on December 10, 1817, and elects senators to class 1 and class 2. Its current senators are Republicans Cindy Hyde-Smith and Roger Wicker. As of February 2022, 51 people have served as U.S. senators from Mississippi. John C. Stennis was Mississippi's longest-serving senator (1947–1989).
Mississippi last elected a Democrat in 1982, and both seats have been occupied by the Republicans since 1989.
List of senators
|- style="height:2em" ! rowspan=2 | 1 | rowspan=2 align=left | Walter Leake | rowspan=2 | Democratic-Republican | rowspan=2 nowrap | Dec 10, 1817 –May 15, 1820 | rowspan=2 | Elected in 1817.Resigned. | rowspan=4 | 1 | | rowspan=5 | 1 | rowspan=5 | Elected in 1817. | rowspan=11 nowrap | Dec 10, 1817 –Mar 3, 1829 | rowspan=6 | Democratic-Republican | rowspan=11 align=right | Thomas Hill Williams ! rowspan=11 | 1
|- style="height:2em"
|- style="height:2em" | colspan=3 | Vacant | nowrap | May 15, 1820 –Aug 30, 1820
|- style="height:2em" ! rowspan=4 | 2 | rowspan=4 align=left | David Holmes | rowspan=3 | Democratic-Republican | rowspan=4 nowrap | Aug 30, 1820 –Sep 25, 1825 | Elected to finish Leake's term.
|- style="height:2em" | rowspan=3 | Re-election year unknown.Resigned to become Governor of Mississippi. | rowspan=6 | 2
|- style="height:2em" | | rowspan=6 | 2 | rowspan=6 | Re-elected in 1823.
|- style="height:2em" | | Jacksonian | rowspan=4 | rowspan=5 | Jacksonian
|- style="height:2em" | colspan=3 | Vacant | nowrap | Sep 25, 1825 –Sep 28, 1825
|- style="height:2em" ! 3 | align=left | Powhatan Ellis | | Jacksonian | nowrap | Sep 28, 1825 –Jan 28, 1826 | Appointed to continue Holmes's term.Lost election to finish Holmes's term.
|- style="height:2em" ! 4 | align=left | Thomas Buck Reed | | Jacksonian | nowrap | Jan 28, 1826 –Mar 3, 1827 | Elected to finish Holmes's term.Lost election to full term.
|- style="height:2em" ! rowspan=7 | 5 | rowspan=7 align=left | Powhatan Ellis | rowspan=7 | Jacksonian | rowspan=7 nowrap | Mar 4, 1827 –Jul 16, 1832 | rowspan=7 | Election year unknown.Resigned to become a U.S. District Judge. | rowspan=9 | 3
|- style="height:2em" | rowspan=5 | rowspan=10 | 3 | Elected in 1828.Died. | nowrap | Mar 4, 1829 –Nov 26, 1829 | | Jacksonian | align=right | Thomas Buck Reed ! 2
|- style="height:2em"
| nowrap | Nov 26, 1829 –Jan 6, 1830 | colspan=3 | Vacant
|- style="height:2em" | Elected to finish Reed's term.Died. | nowrap | Jan 6, 1830 –Jul 2, 1830 | | Jacksonian | align=right | Robert H. Adams ! 3
|- style="height:2em"
| nowrap | Jul 2, 1830 –Oct 15, 1830 | colspan=3 | Vacant
|- style="height:2em" | rowspan=6 | Appointed to continue Adams's term.Elected in 1830 to finish Adams's term.Lost re-election. | rowspan=6 nowrap | Oct 15, 1830 –Mar 3, 1835 | | Jacksonian | rowspan=6 align=right | George Poindexter ! rowspan=6 | 4
|- style="height:2em" | | rowspan=5 | NationalRepublican
|- style="height:2em" | colspan=3 | Vacant | nowrap | Jul 16, 1832 –Nov 12, 1832
|- style="height:2em" ! rowspan=5 | 6 | align=left | John Black | | Jacksonian | nowrap | Nov 12, 1832 –Mar 3, 1833 | Appointed to finish Ellis's term.
|- style="height:2em" | colspan=2 | Vacant | nowrap | Mar 4, 1833 –Nov 22, 1833 | Legislature failed to elect. | rowspan=7 | 4 | rowspan=2
|- style="height:2em" | rowspan=3 align=left | John Black | rowspan=2 | NationalRepublican | rowspan=3 nowrap | Nov 22, 1833 –Jan 22, 1838 | rowspan=3 | Elected late.Resigned.
|- style="height:2em" | | rowspan=6 | 4 | rowspan=6 | Elected in 1835. | rowspan=9 nowrap | Mar 4, 1835 –Mar 5, 1845 | | Jacksonian | rowspan=9 align=right | Robert J. Walker ! rowspan=9 | 5
|- style="height:2em" | | Whig | rowspan=4 | rowspan=8 | Democratic
|- style="height:2em" ! 7 | align=left | James F. Trotter | | Democratic | nowrap | Jan 22, 1838 –Jul 10, 1838 | Appointed to continue Black's term.Resigned.
|- style="height:2em" | colspan=3 | Vacant | nowrap | Jul 10, 1838 –Nov 12, 1838
|- style="height:2em" ! 8 | align=left | Thomas H. Williams | | Democratic | nowrap | Nov 12, 1838 –Mar 3, 1839 | Appointed to continue Black's term.Elected in 1839 to finish Black's term..
|- style="height:2em" ! rowspan=3 | 9 | rowspan=3 align=left | John Henderson | rowspan=3 | Whig | rowspan=3 nowrap | Mar 4, 1839 –Mar 3, 1845 | rowspan=3 | Elected in 1838.. | rowspan=3 | 5
|- style="height:2em" | | rowspan=5 | 5 | rowspan=3 | Re-elected in 1841.Resigned to become U.S. Secretary of the Treasury.
|- style="height:2em"
|- style="height:2em" ! rowspan=4 | 10 | rowspan=4 align=left | Jesse Speight | rowspan=4 | Democratic | rowspan=4 nowrap | Mar 4, 1845 –May 1, 1847 | rowspan=4 | Elected in 1844.Died. | rowspan=7 | 6
|- style="height:2em"
| nowrap | Mar 5, 1845 –Nov 3, 1845 | colspan=3 | Vacant
|- style="height:2em" | Appointed to continue Walker's term.Elected in 1846 to finish Walker's term.. | nowrap | Nov 3, 1845 –Mar 3, 1847 | | Democratic | align=right | Joseph W. Chalmers ! 6
|- style="height:2em" | | rowspan=10 | 6 | rowspan=7 | Elected in 1846 or 1847.Resigned to become Governor of Mississippi. | rowspan=7 nowrap | Mar 4, 1847 –Jan 8, 1852 | rowspan=7 | Democratic | rowspan=7 align=right | Henry S. Foote ! rowspan=7 | 7
|- style="height:2em" | colspan=3 | Vacant | nowrap | May 1, 1847 –Aug 10, 1847
|- style="height:2em" ! rowspan=3 | 11 | rowspan=3 align=left | Jefferson Davis | rowspan=3 | Democratic | rowspan=3 nowrap | Aug 10, 1847 –Sep 23, 1851 | rowspan=2 | Appointed to continue Speight's term.Elected in 1848 to finish Speight's term.
|- style="height:2em"
|- style="height:2em" | Re-elected in 1850.Resigned to run for Governor of Mississippi. | rowspan=9 | 7 | rowspan=6
|- style="height:2em" | colspan=3 | Vacant | nowrap | Sep 23, 1851 –Dec 1, 1851
|- style="height:2em" ! rowspan=3 | 12 | rowspan=3 align=left | John J. McRae | rowspan=3 | Democratic | rowspan=3 nowrap | Dec 1, 1851 –Mar 17, 1852 | rowspan=3 | Appointed to continue Davis's term.Successor elected.
|- style="height:2em"
| nowrap | Jan 8, 1852 –Feb 18, 1852 | colspan=3 | Vacant
|- style="height:2em" | rowspan=2 | Elected to finish Foote's term.Retired. | rowspan=2 nowrap | Feb 18, 1852 –Mar 3, 1853 | rowspan=2 | Whig | rowspan=2 align=right | Walker Brooke ! rowspan=2 | 8
|- style="height:2em" ! rowspan=4 | 13 | rowspan=4 align=left | Stephen Adams | rowspan=4 | Democratic | rowspan=4 nowrap | Mar 17, 1852 –Mar 3, 1857 | rowspan=4 | Elected to finish Davis's term..
|- style="height:2em" | rowspan=2 | rowspan=4 | 7
| nowrap | Mar 4, 1853 –Jan 7, 1854 | colspan=3 | Vacant
|- style="height:2em" | rowspan=3 | Elected late in 1854 | rowspan=4 nowrap | Jan 7, 1854 –Jan 12, 1861 | rowspan=4 | Democratic | rowspan=4 align=right | Albert G. Brown ! rowspan=4 | 9
|- style="height:2em"
|- style="height:2em" ! rowspan=3 | 14 | rowspan=3 align=left | Jefferson Davis | rowspan=3 | Democratic | rowspan=3 nowrap | Mar 4, 1857 –Jan 21, 1861 | rowspan=3 | Elected in 1856 or 1857.Resigned. | rowspan=5 | 8
|- style="height:2em" | | rowspan=5 | 8 | Re-elected in 1859.Withdrew.
|- style="height:2em" | rowspan=7 | Civil War and Reconstruction | rowspan=7 nowrap | Jan 12, 1861 –Feb 23, 1870 | rowspan=7 colspan=3 | Vacant
|- style="height:2em" | rowspan=6 colspan=3 | Vacant | rowspan=6 nowrap | Jan 21, 1861 –Feb 23, 1870 | rowspan=6 | Civil War and Reconstruction
|- style="height:2em"
|- style="height:2em" | rowspan=3 | 9
|- style="height:2em" | | rowspan=4 | 9
|- style="height:2em"
|- style="height:2em" | rowspan=6 | 10 | rowspan=2
|- style="height:2em" ! rowspan=4 | 15 | rowspan=4 align=left | Adelbert Ames | rowspan=4 | Republican | rowspan=4 nowrap | Feb 23, 1870 –Jan 10, 1874 | rowspan=4 | Elected in 1870 upon readmission.Resigned to become Governor of Mississippi. | Elected in 1870 upon readmission.. | nowrap | Feb 23, 1870 –Mar 3, 1871 | | Republican | align=right | Hiram R. Revels ! 10
|- style="height:2em" | rowspan=2 | rowspan=6 | 10
| nowrap | Mar 4, 1871 –Dec 1, 1871 | colspan=3 | Vacant
|- style="height:2em" | rowspan=5 | Elected in 1870, but remained Governor until Dec 1871.. | rowspan=5 nowrap | Dec 1, 1871 –Mar 3, 1877 | rowspan=5 | Republican | rowspan=5 align=right | James L. Alcorn ! rowspan=5 | 11
|- style="height:2em"
|- style="height:2em" | colspan=3 | Vacant | nowrap | Jan 4, 1874 –Feb 3, 1874
|- style="height:2em" ! 16 | align=left | Henry R. Pease | | Republican | nowrap | Feb 3, 1874 –Mar 3, 1875 | Elected to finish Ames's term.Retired.
|- style="height:2em" ! rowspan=3 | 17 | rowspan=3 align=left | Blanche Bruce | rowspan=3 | Republican | rowspan=3 nowrap | Mar 4, 1875 –Mar 3, 1881 | rowspan=3 | Elected in 1874.. | rowspan=3 | 11
|- style="height:2em" | | rowspan=3 | 11 | rowspan=3 | Elected in 1876. | rowspan=5 nowrap | Mar 4, 1877 –Mar 6, 1885 | rowspan=5 | Democratic | rowspan=5 align=right | Lucius Q. C. Lamar ! rowspan=5 | 12
|- style="height:2em"
|- style="height:2em" ! rowspan=13 | 18 | rowspan=13 align=left | James Z. George | rowspan=13 | Democratic | rowspan=13 nowrap | Mar 4, 1881 –Aug 14, 1897 | rowspan=5 | Elected in 1880. | rowspan=5 | 12
|- style="height:2em" | | rowspan=5 | 12 | rowspan=2 | Re-elected in 1883.Resigned.
|- style="height:2em"
|- style="height:2em"
| nowrap | Mar 6, 1885 –Mar 9, 1885 | colspan=3 | Vacant
|- style="height:2em" | rowspan=2 | Appointed to continue Lamar's term.Elected in 1886 to finish Lamar's term. | rowspan=5 nowrap | Mar 9, 1885 –Jan 24, 1894 | rowspan=5 | Democratic | rowspan=5 align=right | Edward C. Walthall ! rowspan=5 | 13
|- style="height:2em" | rowspan=3 | Re-elected in 1886. | rowspan=3 | 13
|- style="height:2em" | | rowspan=5 | 13 | rowspan=3 | Re-elected in 1889.Resigned.
|- style="height:2em"
|- style="height:2em" | rowspan=5 | Re-elected in 1892.Died. | rowspan=9 | 14
|- style="height:2em"
| nowrap | Jan 24, 1894 –Feb 7, 1894 | colspan=3 | Vacant
|- style="height:2em" | Elected to finish Walthall's term.. | nowrap | Feb 7, 1894 –Mar 3, 1895 | | Democratic | align=right | Anselm J. McLaurin ! 14
|- style="height:2em" | | rowspan=7 | 14 | rowspan=4 | Elected early in 1892.Died. | rowspan=4 nowrap | Mar 4, 1895 –Apr 21, 1898 | rowspan=4 | Democratic | rowspan=4 align=right | Edward C. Walthall ! rowspan=4 | 15
|- style="height:2em" | rowspan=5
|- style="height:2em" | colspan=3 | Vacant | nowrap | Aug 14, 1897 –Oct 8, 1897
|- style="height:2em" ! rowspan=12 | 19 | rowspan=12 align=left | Hernando Money | rowspan=12 | Democratic | rowspan=12 nowrap | Oct 8, 1897 –Mar 3, 1911 | rowspan=3 | Appointed to finish George's term.
|- style="height:2em"
| nowrap | Apr 21, 1898 –May 31, 1898 | colspan=3 | Vacant
|- style="height:2em" | rowspan=2 | Appointed to continue Walthall's term.Elected in 1900 to finish Walthall's term.Retired. | rowspan=2 nowrap | May 31, 1898 –Mar 3, 1901 | rowspan=2 | Democratic | rowspan=2 align=right | William V. Sullivan ! rowspan=2 | 16
|- style="height:2em" | rowspan=3 | Elected to full term in 1899. | rowspan=3 | 15
|- style="height:2em" | | rowspan=3 | 15 | rowspan=3 | Elected in 1900. | rowspan=5 nowrap | Mar 4, 1901 –Dec 22, 1909 | rowspan=5 | Democratic | rowspan=5 align=right | Anselm J. McLaurin ! rowspan=5 | 17
|- style="height:2em"
|- style="height:2em" | rowspan=6 | Re-elected in 1904.Retired. | rowspan=6 | 16
|- style="height:2em" | | rowspan=6 | 16 | rowspan=2 | Re-elected early in 1904.Died.
|- style="height:2em" | rowspan=4
|- style="height:2em"
| nowrap | Dec 22, 1909 –Dec 27, 1909 | colspan=3 | Vacant
|- style="height:2em" | Appointed to continue McLaurin's term.Successor qualified. | nowrap | Dec 27, 1909 –Feb 22, 1910 | | Democratic | align=right | James Gordon ! 18
|- style="height:2em" | rowspan=2 | Elected to finish McLaurin's term.Lost nomination to full term. | rowspan=2 nowrap | Feb 23, 1910 –Mar 3, 1913 | rowspan=2 | Democratic | rowspan=2 align=right | LeRoy Percy ! rowspan=2 | 19
|- style="height:2em"