These United States submarines were lost either to enemy action or to "storm or perils of the sea."

Before World War II Ship name Hull number Date of loss Fate Approximate location Turtle NA Tender vessel sunk by BritishDiamant, p. 33 Fort Lee, New Jersey NA Broke loose from tow and foundered Cape Hatteras, North Carolina SS-20 Lost in collision with San Diego, California SS-23 Foundered due to battery acid leak Honolulu, Hawaii SS-28 Grounded Magdalena Bay, Mexico SS-66 Collided with SS Abangarez Bahía Limón, Panama SS-70 Foundered on test dive Isles of Shoals, New Hampshire SS-109 Collided with Coast Guard destroyer ;raised and recommissioned 16 October 1928 Provincetown, Massachusetts SS-110 Foundered on dive Delaware Capes, New Jersey SS-162 Collided with SS City of Rome Block Island, Rhode Island SS-192 Foundered on test dive; raised and renamed Sailfish Isles of Shoals, New Hampshire

Additionally: , decommissioned as a target, flooded and sank unexpectedly 30 July 1919 in Two Tree Channel near Niantic, Connecticut with the loss of three crew. foundered 7 December 1921 in of water on a pre-commissioning dive. She was raised and commissioned 14 October 1922. , decommissioned on 2 May 1931, she was berthed at Philadelphia until 26 February 1936 when she sank at her mooring. Later raised, she was struck from the Naval Vessel Register on 12 May 1936 and on 19 August she was used as a target vessel for an aerial bombing test.

During World War II American submarine losses

During World War II, the U.S. Navy's submarine service suffered one of the highest casualty percentage of all the American armed forces, losing one in five submariners.Blair, pp. 877 Some 16,000 submariners served during the war, of whom 375 officers and 3,131 enlisted men were killed, resulting in a total fatality rate of around 22%.Blair, p. 877.

Fifty-two submarines of the United States Navy were lost during World War II, all but one, , in the Pacific theater of operations.″United States Submarine Losses World War II″, Naval History Division, Office of the Chief of Naval Operations, Washington: 1963 (Fifth Printing) Two – Dorado (SS-248) and – were lost to friendly fire (though there is speculation that the Dorado may have struck a German mine), at least three more – Tulibee, Tang, and Grunion – to defective torpedoes, and six to accident or grounding.Blair, Clay, Jr. Silent Victory (Philadelphia: Lippincott, 1975), pp. 991–92, .

Another eight submarines went missing while on patrol and are presumed to have been sunk by Japanese mines, as there are no known Japanese anti-submarine attacks in their patrol areas. The other thirty-three lost submarines are known to have been sunk by the Japanese.

Ship name Hull number Date of loss Fate Approximate location SS-218 Lost to enemy mine Northeast of Hokkaido SS-219Missing after 14 February 1943 Possibly lost to enemy action by torpedo boat Hiyodori and submarine chaser No. 18 New Britain SM-1 Sunk by Japanese destroyers Isokaze and Maikaze New Britain SS-316 Lost to enemy air attack Borneo SS-223 Lost to enemy action: depth-charged by kaibōkan Okinawa, CD-63, CD-75, CD-158, and CD-207 Sea of Japan SS-332 Lost to enemy air attack; last US submarine loss of the war Java Sea SS-289Missing after 2 December 1943 Fate unknown; possible naval mine or attack by minelayer Wakataka Celebes Sea SS-290 Lost to air attack and gunboat Karatsu (ex-USS Luzon) Mindanao SS-226 Torpedoed and sunk by Truk SS-227 Accidental grounding in pursuit of Japanese cruiser Takao Palawan Passage SS-248Missing after 6 October 1943 Fate unknown; possibly sunk by friendly fire air attack (PBM Mariner of Patrol Squadron 210) or mines from Panama Canal Zone SS-294Missing after 17 October 1944 Fate unknown; possibly naval mine or a Japanese escort destroyer Yellow Sea SS-250 Lost to enemy mine Balabac Strait, Philippines (7°58'43.21"N 117°15'23.79"E) SS-361 Lost to enemy action by escorts Miya Maru and Bunzan Maru Northern Japanese waters SS-207Missing after 11 February 1943 Fate unknown; possibly sunk by Japanese destroyers Minegumo and Murasame (or possibly to air attack by 958th Kōkūtai naval aircraft) New Britain SS-208 Lost to enemy air attack Ryukyu Islands SS-209Missing after 9 September 1943 Fate unknown; possibly rammed by transport Hokuan Maru Lingayen Gulf, Philippines SS-210 Scuttled following enemy air attack Strait of Malacca SS-215 Sunk by Japanese destroyer Shigure and escort ships Chiburi and CD-19 Philippines SS-216 Sunk by circular run of own torpedo Kiska Island, Alaska SS-211Missing after 7 April 1944 Fate unknown; possibly air attack Maug Islands or possibly Iwo Jima SS-257 Lost to enemy action by kaibokan CD-22 Dasol Bay, Philippines SS-233 Lost to enemy shore batteries Kuril Islands SS-369Missing after 19 March 1945 Fate unknown; possibly sunk by mines Ryukyu Islands SS-371 Lost to enemy action by Japanese minelayer Hatsutaka Gulf of Thailand SS-176 1- Scuttled following enemy action by Japanese destroyers Amatsukaze, Hatsukaze, Ushio, and Sazanami Java SS-177Missing after 18 March 1943 Fate unknown; possible enemy actions include one by minelayer Shirakami and auxiliary subchaser Bunzan Maru on 3 April 1943 Northern Honshu SS-181Missing after 27 August 1943 Fate unknown; possibly naval mine or enemy action Northern Honshu SS-89 Foundered on training exercise off Key West, Florida SS-273 Fate unknown; probably naval mine West of Palawan Island SS-275Missing after 27 May 1943 Fate unknown; possibly naval mine Hokkaido SS-131 Accidental collision with Gulf of Panama SS-132 Accidental grounding Amchitka Island, Alaska SS-133 Foundered while submerged during anti-submarine exercise (reasons unknown) Oahu, Hawaii SS-141 Accidental grounding Makassar Strait SS-144 Accidental grounding Rossel Island SS-155 Lost to enemy action by Japanese escort Ishigaki Kurile Islands SS-277 Lost to enemy action by kaibokan CD-4 and aircraft Tokyo Bay SS-278Missing after 5 January 1944 Fate unknown; probably naval mine East China Sea SS-191 Scuttled following enemy action by Japanese destroyer Yamagumo Gilbert Islands SS-195 Scuttled 25 December 1941 following irreparable damage in air attack 10 December Cavite Navy Yard, Philippines SS-197 Probably sunk by "friendly fire" from Morotai Island SS-174Missing after 7 February 1942 Probably sunk by Japanese destroyer Yamakaze Molucca Sea SS-314 Sunk by Japanese destroyer Harukaze Luzon Strait SS-279Missing after 8 April 1945 Fate unknown; possibly sunk by Japanese escort ships Okinawa, CD-8, CD-32 and CD-52 South China Sea SS-193Missing after 3 January 1945 Fate unknown; possibly sunk by Japanese escort ship CD-4 or naval mine Ryukyu Islands SS-306 Sunk by circular run of own torpedo Formosa Strait SS-237 Lost to enemy action by kaibokan Mikura, CD-33, and CD-59; assisted by air attack Ryukyu Islands SS-201 Sunk by Japanese destroyers Samidare and Satsuki and submarine chasers CH-22 and CH-24 Admiralty Islands SS-202 Sunk by Japanese destroyer Asashimo Okinawa SS-284 Sunk by circular run of own torpedo Palau Islands SS-238 Lost to enemy air and surface attack by submarine chasers CH-15, CH-43 and 3 E13A1 Jakes La Perouse Strait

Additional casualties There are two additional casualties to submarines in World War II that are sometimes considered as effectively two additional losses.

was damaged by Japanese air and surface forces on 14 November 1944. She was able to reach Saipan and later Pearl Harbor on 1 December, departing San Francisco for Portsmouth Navy Yard on 16 February 1945. There it was determined that she was a constructive total loss and beyond economical repair, but might be useful as a school ship, similar to the postwar immobile pierside training submarines. However, her career in this capacity was brief, and Halibut was decommissioned at Portsmouth Navy Yard 18 July 1945 and sold for scrap in January 1947.

was commissioned on 12 February 1945 and sank at pier 8 at the Boston Navy Yard on 15 March 1945, apparently without loss of life and reportedly still incomplete. She was raised eight days later, decommissioned on 24 March 1945, and never completed or fully repaired.Bauer & Roberts, p. 275Friedman through 1945, p. 297Silverstone, p. 199 Postwar, she was listed as a Reserve Fleet submarine until stricken in 1958 and scrapped in 1959, having never gone to sea.

Additional incidents The former was transferred to the Royal Navy 9 March 1942 and renamed as HMS P.514. On 21 June 1942 she was rammed by the Royal Canadian Navy minesweeper and sank with all hands after the submarine was mistaken for a German U-boat.

The former was sold in 1931 to a private owner for use as a tourist attraction, with the hulk reacquired by the U.S. Navy for "experimental purposes" in 1941. She foundered and sank in the Patuxent River 16 December 1942.

The former was transferred to the Royal Navy 4 November 1941 and renamed as RMS P.551 then transferred to the Polish Navy in exile and renamed . On 2 May 1942 she was attacked in a friendly fire incident by a Royal Navy minesweeper and destroyer and sank with all hands.

, originally commissioned on 16 December 1918 and decommissioned after more than 12 years of service, was recommissioned and served for five additional years during World War II. R-1 was decommissioned at Key West on 20 September 1945 and was struck from the Naval Vessel Register on 10 November. Still at Key West awaiting disposal on 21 February 1946, the submarine sank in of water. Raised three days later, she was sold for scrap on 13 March 1946.

was decommissioned on 6 February 1945, was stripped, and her hulk was supposed to be expended as a target for aerial bombing off San Diego, California, but she broke her tow cable and sank, coming to rest in some of water, on 20 February 1945. Her name was stricken from the Naval Vessel Register three days later. Salvagers unsuccessfully tried to retrieve the wreck of S-37 for her scrap value, but lost her again off Imperial Beach, California, in of water at , where she remains to this day.

After World War II Ship name Hull number Date of loss Fate Approximate location SS-345 Lost to accidental fire and battery explosion Norwegian Sea SSN-589Between 22 May and 5 June 1968 Cause unknown; numerous theories have been advanced. Recent deep submergence photography indicates the possibility of an implosion event similar to the USS Thresher. North Atlantic Ocean, southwest of the Azores SS-415 Collision with Oahu, Hawaii SSN-593 Exact cause unknown; one theory is a seawater leak led to a reactor plant shutdown, compounded by a heavy trim (excess negative buoyancy) and an inadequate ballast tank blow system. Another theory is that a reactor plant scram occurred for tests; a flaw caused an inability to operate key reactor valves and other valves, which prevented emergency surfacing or a problem in the procedures for a scram caused the inability to operate a very important steam plant valve causing a loss of propulsion. Any of these problems could have caused the boat to sink beyond crush depth. east of Cape Cod, Massachusetts

Additional incidents was decommissioned on 15 November 1945 and sold for scrap 8 June 1957. The Tarpon foundered in deep water, south of Cape Hatteras, North Carolina, on 26 August 1957, while under tow to the scrap yard.