Optimo may refer to:
Optimo Espacio, night club in Glasgow, Scotland Optimo (EP), a 1983 EP by post-punk band Liquid Liquid Optimo cigars, made by Swisher International Group Deo optimo maximo, Latin phrase meaning "to the greatest and best God" De optimo senatore, Latin treatise by Wawrzyniec Goślicki published in 1568 Caetano Optimo, minibus manufactured by Salvador Caetano