Khama is the name of the royal family of the Bamangwato people of Botswana. As such, it may refer to:

Khama III (1837? – 1923), kgosi (chief/king) of the Bamangwato people of Bechuanaland (now Botswana) Semane Setlhoko Khama (1881 – 1937), mohumagadi (queen) of the Bamangwato people of Bechuanaland, fourth wife of Khama III Tshekedi Khama (1905 – 1959), regent of the Bamangwato tribe in 1926 after the death of Sekgoma II Seretse Khama (1921 – 1980), the first President of Botswana, in office from 1966 to 1980 Sir Seretse Khama International Airport, named after the above Ruth Williams Khama (1923 – 2002), wife of Seretse Khama, First Lady of Botswana from 1966 to 1980 Ian Khama (1953), first-born son of Seretse and Ruth Williams Khama and President of Botswana from 2008 to 2018 Tshekedi Khama II (1958), son of Seretse and Ruth Williams Khama and a former Botswana MP

Other people with this name: Khama Billiat, a Zimbabwean professional footballer

In astronomy, 1357 Khama is a main-belt asteroid discovered on July 2, 1935, by Cyril Jackson.

Khama can also be a transliteration of Hebrew חַמָּה (chammah), meaning "heat"/"rage". When used as a proper noun, it can refer to both Mercury as well as the Sun.

See also Karma, called "kamma" in Pali Kama, another concept from Indian religious thought Kamma (disambiguation) Cama (disambiguation) Qama, a short Persian sword Kahma, an Indian village Pentti Kahma, a retired discus thrower from Finland Kham, a historical region of Tibet Khamag Mongol, a major Mongolic tribal confederation in the 12th century Khamaj, a parent scale in Hindustani music Khamal (disambiguation) Khaman, an Indian dish Khamar, a village in Yemen Khamar Monastery, a Buddhist center in Mongolia Khamas, Khuzestan, an Iranian village Khamas (raga), a Carnatic music scale Birkat Hakhama, a Jewish blessing thanking God for creating the sun Khame Mi, the first chief queen consort of King Swa Saw Ke of the Ava Kingdom Khami, the now-ruined capital of the pre-colonial Kingdom of Butua Khamir (disambiguation) Khamis (disambiguation) Khamo, a village in Myanmar Khamachon, an Indian village Khamaneh, an Iranian city Khammam, an Indian city Khammu/Khmu, an ethnic group of Southeast Asia Ayya Khema, a Buddhist teacher Khoma, a progressive/alternative metal musical group from Sweden Khamsa (disambiguation) Kshama Sawant, an American socialist politician Khanna (disambiguation)