S63 may refer to:

Aviation Savoia-Marchetti S.63, an Italian flying boat Sikorsky S-63, an American helicopter Skyharbor Airport, in Dallas County, Alabama, United States

Other uses S-63 (encryption standard), securing electronic navigational chart data S63 (Long Island bus), United States BMW S63, an automobile engine , a submarine of the Indian Navy Mercedes-Benz S63 AMG, a German sedan S63: In case of accident by inhalation: remove casualty to fresh air and keep at rest, a safety phrase

S63, a postcode district for Rotherham, England