Wilkes is a surname of English origin, a variant of the name William. Notable people with the surname include:

Albert Wilkes (1874–1936), English sports photographer and football player Alice Wilkes, lady in waiting to Queen Katherine Howard Alexander Wilkes (1900–1937), English cricketer Ally Wilkes, English author Belinda Wilkes, English astrophysicist Benjamin Wilkes (died c.1749), British entomological painter Brent A. Wilkes, executive director of the League of United Latin American Citizens Brent R. Wilkes (born 1954), American defense contractor Carissa Wilkes (born 1986), New Zealand road cyclist Cathy Wilkes (born 1966), Northern Ireland artist Charles Wilkes (banker) (1764–1833), British born American banker Charles Wilkes (1798–1877), American naval officer and explorer Dave Wilkes (born 1964), English professional football player Debbi Wilkes (born 1946), Canadian figure skater and author Del Wilkes (born 1961), American wrestler Donald E. Wilkes Jr. (1944–2019), American legal scholar Donna Wilkes (born 1959), American film actress Faas Wilkes (1923–2006), Dutch football player Frank Wilkes (1922–2015), Australian politician Frederick Wilkes (1869–after 1892), English football player Fred Wilkes (1883–1942), English football player George Wilkes (1817–1885), American journalist and newspaper editor Glenn Wilkes Sr. (1928–2020), American college basketball coach and author Glenn Wilkes Jr. (born 1958), American college basketball player and coach Ian Wilkes (born 1965), Australian racehorse trainer in the US India Wilkes, fictional character in American novel and film Gone with the Wind J. D. Wilkes (born 1972), American musician Jamaal Wilkes (born 1953), American basketball player, formerly Keith Wilkes James Wilkes (disambiguation), several people Jane Renwick Smedburg Wilkes (1827–1913), American nurse and philanthropist Joanne Wilkes (born 1956), New Zealand professor of English literature John Wilkes (disambiguation), several people Jon Wilkes (born 1985), American drummer Jonathan Wilkes (born 1978), English television presenter, actor and musician Joseph Wilkes (1733–1805), English industrialist and agricultural improver Justin Wilkes, British film producer Kathy Wilkes (1946–2003), English philosopher and academic Kris Wilkes (born 1998), American basketball player Lyall Wilkes (1914–1991), English historian, judge and politician

Mary Allen Wilkes (born 1937), American computer programmer and hardware engineer Maurice Wilkes (1913–2010), British computer scientist Maya Wilkes, fictional character in American TV sitcom Girlfriends Melanie Wilkes, fictional character in American novel and film Gone with the Wind Michael Wilkes (1940–2013), British army general Oliver Wilkes (born 1980), British rugby player Oren Wilkes (born 1988), American fashion model and blogger Owen Wilkes (1940–2005), New Zealand peace campaigner Paget Wilkes (1871–1934), English missionary in Japan Paul Wilkes (born 1938), American author on Catholicism Peter Singleton Wilkes (1827–1900), American Confederate politician Reggie Wilkes (born 1956), American football player Rich Wilkes (born 1966), American filmmaker Richard Wilkes (16th century), English priest and academic Richard Wilkes (antiquarian) (1691–1760), English physician and antiquarian Robert Wilkes (1832–1880), Irish-Canadian politician and businessman Robert Wilkes (priest) (born 1948), Church of England priest Rodney Wilkes (1925–2014), Trinidadian weightlifter Sam Wilkes (born 1991), American bassist Sarah Wilkes (born 1990), Canadian curler Sema Wilkes (1907–2002), business owner and writer Stephen Wilkes, American photographer Steve Wilkes (born 1967), English football player T. M. Wilkes (1888–1958), Controller of Civil Aviation in New Zealand Thomas Wilkes (Chippenham MP) (by 1508–1536/37), English politician Thomas Wilkes (c.1545–1598), English civil servant and diplomat Tom Wilkes (footballer) (1874–1921), English football player Tom Wilkes (1939–2009), American art director, designer, photographer, illustrator, writer and producer-director William Wilkes (1865–1940), English cricketer

Fictional characters Annie Wilkes, fictional character in the Stephen King novel and film Misery Ashley Wilkes, fictional character in American novel and film Gone with the Wind Sergeant Wilkes, fictional character in the film, Dracula's Daughter

See also Wilks Wilke Weelkes