DR1 binding pocket with ligand major histocompatibility complex, class II, DR1 Haplotypes groups DRA*01:DRB1*01:01 DRA*01:DRB1*01:02 DRA*01:DRB1*01:03 Structure (See HLA-DR) Identifiers alpha *01:01 Symbol(s) HLA-DRA EBI-HLA DRA *01:01 Identifiers beta 1 *01:01, *01:02, *01:03 . . . Symbol(s) HLA-DRB1 Shared data Locus chr.6 6p21.31
HLA-DR1 (DR1) is a HLA-DR serotype that recognizes the DRB1*01 gene products. It has been observed to be common among centenarians.
Serology + DR1 serotype recognition of Some DRB1*01 allele-group gene productsderived from IMGT/HLA DRB1* DR1 DR103 Sample allele % % % size (N) 97% 6317 95% 2035 56% 12% 1186 >50% 2
The serology for the most common DR1 alleles is excellent. The serology for alleles , , , , , , and is unknown.
Disease associations
By serotype DR1 is associated with seronegative-rheumatoid arthritis, penicillamine-induced myasthenia, and schizophrenia. DR1 is increased in patients with systemic sclerosis and arthritis and in ulcerative colitis with patients that have articular manifestations.
By allele DRB1*01:01 is associated with rheumatoid arthritis, in anti-Jk(a) mediated hemolytic transfusion reactions, foliaceous pemphigus, HTLV-1-associated myelopathy/tropical spastic paraparesis, and lichen planus. In lyme disease arthritis, *01:01 appears to play a role in presentation of triggering microbial antigens.
DRB1*01:02 is associated with rheumatoid arthritis, in anti-Jk(a) mediated hemolytic transfusion reactions, psoriasis vulgaris, and recurrent respiratory papillomatosis
DRB1*01:03 is associated with colonic Crohn's disease and ulcerative colitis.
By genotype DRB1*01:01/*0404 and *01:01/*0401 increases risk of mortality in rheumatoid arthritis, with ischemic heart disease and smoking. these same genotypes are associated with rheumatoid vasculitis.
By haplotype DRB1*01:02:DQB1*05:01 is associated with psoriasis vulgaris and tubulointerstitial nephritis & uveitis syndrome, but is relatively protective against juvenile diabetes.
DR1-DQ5 is associated with tubulointerstitial nephritis & uveitis syndrome.
Rheumatoid arthritis There frequency of DR4-DQ8 haplotypes reach extreme nodal levels. Arthritis has been identified in a pre-Columbian remains from Italy, the affected individual bearing the DRB1*01:01 allele. DRB1*01:01 and most DR4 have in common a 'shared epitope'. In this hypothesis a common region of the beta chain, positions 67 to 74, are common and may be integral to presenting auto-immunological peptides.
Genetic linkage DR1 Haplotypes Serotypes DRA DRB1 DR1 *01:01 *01:01 *01:01 *01:02 *01:01 *01:03 Serotypes DQA1 DQB1 DRB1 DR1-DQ5 (5.1, 1) *01:01 *05:01 *01:01 *01:01 *05:01 *01:02 *01:01 *05:01 *01:03 Serotypes HLA-A HLA C HLA B DRB1 A3-Cw4-B35-DR1 *03:01 *04:01 *35:01 *01:01 A11-Cw4-B35-DR1 *11:01 *04:01 *35:01 *01:03 A33-Cw8-B14-DR1 *33:01 *08:02 *14:02 *01:02
HLA-DR1 is not genetically linked to DR51, DR52 or DR53, but is linked to HLA-DQ1 and DQ5 serotypes.
References