H16 or H-16 may refer to:
Transport Curtiss H-16, a 1914 American Curtiss Model H flying boat variant H16 engine, a type of H engine like the Fairey H-16 HMS Daring (H16), a 1932 British Royal Navy D Class destroyer , a World War I British Royal Navy H class submarine LSWR H16 class, a British LSWR locomotive Piasecki H-16, a tandem-rotor helicopter
Other uses H16, a type of heath community in the British National Vegetation Classification H16, a Slovak rap group named after the former Hálova 16 elementary school, Majk Spirit is one of their members H-16 County Highway, an alternative name for Forest Highway 16. Keratitis, by ICD-10 code