major histocompatibility complex, class II, DR12 Haplotypes groups DQA*01:DRB1*1201 to DQA*01:DRB1*1203 DQA*01:DRB1*1206 Structure (See HLA-DR) Identifiers alpha *0101 Symbol(s) HLA-DRA EBI-HLA DRA*0101 Identifiers beta 1 *1201 to *1203 *1206 Symbol(s) HLA-DRB1 EBI-HLA DRB1*1201 EBI-HLA DRB1*1202 EBI-HLA DRB1*1203 EBI-HLA DRB1*1306 Shared data Locus chr.6 6p21.31
HLA-DR12(DR12) is a HLA-DR serotype that recognizes the DRB1*1201 to *1203, *1206. DR12 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR11 antigens.
Serology + DR12, DR5 and DR11 serotype recognition of the gene products of some DRB1*12 allelesderived from IMGT/HLA DRB1* DR12 DR5 DR11 Sample allele % % % size (N) 1201 83 4 2 893 DR8 - 2% 1202 89 162 1203 >50 3 1206 >50 2
The table above describes the efficiency of serological typing of DR12 and DR5. Serotypes are unknown the following alleles: DRB1*1204,*1205 to *1207 to *1215
Alleles There are only 2 common allels for DRB1*12, *1201 and *1202. *1202 is more common on the West Pacific Rim and particularly Indochina and the South Pacific.
Disease associations DR12 is associated with vulval lichen sclerosus, and undifferentiated spondyloarthritis.
DRB1*1201 is associated with iritis in juvenile arthritis, primary antiphospholipid syndrome, tiopronin intolerance in rheumatoid arthritis, adult chronic articular Still's disease
DRB1*1202 is found to be increased in narcolepsy associated sudden death syndrome in the Thai population, and narcolepsy in the Japanese population.
Extended linkage DRB1*12:DQA1*0505:DQBA1*0301 haplotype: DR12-DQ7.5/DR7-DQ2.2 is a transhaplotype risk for coeliac disease
DRB1*1201:DRB3*01/03: colorectal cancer
Genetic Linkage DR12 Haplotypes Serotypes DRA DRB1 DRB3 DR11(5)-DR52 *0101 *1201 *0101 *0101 *1202 *0201 *0101 *1202 *0202 *0101 *1202 *0301 Serotypes DRB1 DQA1 DQB1 DR12(5)-DQ7 (7.5, 3) *1201 *0505 *0301 *1202 *0505 *0301 DR12(5)-DQ7 (7.3, 3) *1201 *0303 *0301 DR12(5)-DQ7 (7.4, 3) *1201 *0401 *0301 DR12(5)-DQ7 (7.6, 3) *1201 *0601 *0301 Serotypes HLA-A HLA-C HLA-B DRB1 A31(19)-Cw10-B51(5)-DR12(5) *3101 *0304 *5101 *1202 A11-Cw9-B75(15)-DR12(5) *1101 *0303 *1502 *1202 A2-Cw10-B13-DR12(5) *0201 *0304 *1301 *1202
HLA-DR12 is genetically linked to DR52 and HLA-DQ7 serotypes.
References