major histocompatibility complex, class II, DR11 Haplotypes groups DQA*01:DRB1*1101 to DQA*01:DRB1*1111 Structure (See HLA-DR) Identifiers alpha *0101 Symbol(s) HLA-DRA EBI-HLA DRA*0101 Identifiers beta 1 *1101 to *1110 Symbol(s) HLA-DRB1 EBI-HLA DRB1*1101 EBI-HLA DRB1*1102 EBI-HLA DRB1*1103 EBI-HLA DRB1*1104 EBI-HLA DRB1*1105 EBI-HLA DRB1*1106 Shared data Locus chr.6 6p21.31
HLA-DR11 (DR11) is a HLA-DR serotype that recognizes the DRB1*1101 to *1110. DR11 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR12 antigens.
Serology
+ DR11, DR5 and DR12 recognition of the gene products of some DRB1*11 allelesderived from IMGT/HLA DRB1* DR11 DR5 DR12 Sample allele % % % size (N) 1101 92 5 3474 1102 89 3 430 1103 89 4 397 1104 87 4 2119 1105 75 4 1106 20 73 15 1107 >50 1 1108 >50 2 1109 80 20 5
The table above describes the efficiency of serological typing of DR11 and DR5. Serotypes are unknown the following alleles: DRB1*1110 to *1157
Disease associations
By serotype DR11 is associated with grape anaphylaxis, well-differentiated thyroid cancer, low antibody production in Hepatitis C.
By allele(s) DRB1*11 is associated systemic sclerosis (SSc) & anti-DNA topoisomerase I (anti-topo I) antibody
DRB1*1101 is associated Anti-Ro/SSA with anti-La/SSB antibodies in neonatal lupus erythematosus, mite sensitive asthma, cervical cancer risk (HPV?)
DRB1*1102: Tiopronin intolerance in rheumatoid arthritis
DRB1*1104: pauciarticular juvenile rheumatoid arthritis
By haplotype DR11 is an identifier for the DR11-DQ7/DR7-DQ2 transhaplotype isoform of celiac disease. DR11-DQ7.5 is identified as a risk factor in rheumatic heart disease.
DRB1*1101:DQA1*0505:DQB1*0301 haplotype is associated with Anti-Ro/SSA with anti-La/SSB antibodies in neonatal lupus erythematosus, mite sensitive asthma
DRB1*1102:DQA1*0505:DQB1*0301 haplotype is associated with hepatitis B virus persistence
Genetic Linkage DR11 Haplotypes Serotypes DRA DRB1 DRB3 DR11(5)-DR52 *0101 *1101 *02 *0101 *1102 *02 *0101 *1103 *02 *0101 *1104 *02 Serotypes DRB1 DQA1 DQB1 DR11(5)-DQ7 (7.5, 3) *1101 *0505 *0301 *1102 *0505 *0301 *1103 *0505 *0301 *1104 *0505 *0301 Serotypes HLA-A HLA-C HLA-B DRB1 A2-Cw7-B18-DR11 *0201 *0701 *1801 *1104 A24(9)-Cw4-B35-DR11 *2402 *0401 *3501 *1101 A24(9)-Cw14(BL)-B51(5)-DR11 *2402 *1402 *5101 *1104
HLA-DR11 is genetically linked to HLA-DR52 and HLA-DQ7(3) serotypes. The frequency node for DR11 is in the Levant and Anatolia. This serotype more than others appears to have spread with neolithization of Western Europe. The closely linked DQ7.5 appears to be protective against juvenile diabetes, in which wheat consumption appears to be a risk factor.
References