major histocompatibility complex, class II, DR15 Haplotypes groups DRA*01:DRB1*1501 - to - DRA*01:DRB1*1505 DRA*01:DRB1*1507 Structure (See HLA-DR) Identifiers alpha *0101 Symbol(s) HLA-DRA EBI-HLA DRA*0101 Identifiers beta 1 *1501 to *1505 *1507 Symbol(s) HLA-DRB1 EBI-HLA DRB1*1501 EBI-HLA DRB1*1502 EBI-HLA DRB1*1503 EBI-HLA DRB1*1504 EBI-HLA DRB1*1505 EBI-HLA DRB1*1507 Shared data Locus chr.6 6p21.31
HLA-DR15 (DR15) is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high levels from Ireland to Central Asia. DR15 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR16 antigens.
Serology + DR15, DR2 and other serotype recognition of some DRB1*15 allelesderived from IMGT/HLA DRB1* DR15 DR2 DR16 Sample allele % % % size (N) 1501 76 23 6428 1502 77 16 676 1503 81 13 286 1504 >50 1 1505 >25 2 1507 >50 1
Serotypes are unknown for the following alleles: DRB1*1506, *1508 to *1516, *1518 to *1522. DRB1*1517N is a null.
Alleles
Disease associations
DR15 is positively associated Goodpasture syndrome, early age onset multiple sclerosis, pernicious anaemia, sarcoidosis, hypocretin deficiency associated narcolepsy and a predisposition for postmenopausal osteoporosis.
DRB1*1501 is positively associated with Goodpasture syndrome, juvenile rheumatoid arthritis, allergic bronchopulmonary aspergillosis, multiple sclerosis, systemic lupus erythematosus, cervical cancer (human papillomavirus infection), Sjögren syndrome associated with systemic lupus erythematosus, and intermediate uveitis.
DRB1*1502 is associated with systemic lupus erythematosus, systemic sclerosis (SSc) & anti-topoisomerase antibodies.
DRB1*1503 is associated with Chaga's cardiomyopathy, allergic bronchopulmonary aspergillosis, multiple sclerosis, cervical cancer (human papillomavirus infection).
Extended linkage
DRB1*15:DQA1*0102:DQB1*0602 haplotype us associated with cervical cancer risk in (human papillomavirus infection)
DRB1*1502:DQA1*????:DQB1*0501 haplotype is associated with systemic lupus erythematosus
Genetic linkage DR15 Haplotypes Serotypes DRA DRB1 DRB5 DR15(2)-DR51 *0101 *1501 *0101 *0101 *1502 *0101 *0101 *1503 *0101 *0101 *1504 *0101 *0101 *1505 *0101 *0101 *1507 *0101 DQA1 DQB1 DRB1 DR15(2)-DQ6(6.2, 1) *0102 *0602 *1501 DR15(2)-DQ6(6.1, 1) *0103 *0601 *1502 HLA-A HLA-B DRB1 A3-Cw7-B7-DR15(2) *0301 *0702 *1501 A1-B51-DR15(2) *0101 *5101 *1502
HLA-DR15 is genetically linked to HLA-DR51 and HLA-DQ6 (HLA-DQ1) serotypes.
References