major histocompatibility complex, class II, DR16 Haplotypes groups DRA*01:DRB1*1601 DRA*01:DRB1*1602 Structure (See HLA-DR) Identifiers alpha *0101 Symbol(s) HLA-DRA EBI-HLA DRA*0101 Identifiers beta 1 *1601 *1602 *1604 Symbol(s) HLA-DRB1 EBI-HLA DRB1*1601 EBI-HLA DRB1*1602 EBI-HLA DRB1*1604 Shared data Locus chr.6 6p21.31
HLA-DR16(DR16) is a HLA-DR serotype that recognizes the DRB1*1601, *1602 and *1604 gene products. DR16 is found in the Mediterranean at modest frequencies. DR16 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR15 antigens.
Alleles + DR16, DR2 and other serotype recognition of some DRB1*16 allelesderived from IMGT/HLA DRB1* DR16 DR2 DR15 Sample allele % % % size (N) 1601 41 29 19 703 1602 47 30 16 239 1604 >50 1
Disease associations DR16 is associated with Chaga's cardiomyopathy, rheumatic heart disease, coronary artery ectasia, and chronic discoid lupus erythematosus.
DRB1*1601 is associated with tuberculosis risk
DRB1*1602: Juvenile rheumatoid arthritis, rheumatic heart disease, Takayasu arteritis , systemic sclerosis (SSc) & anti-DNA topoisomerase I (anti-topo I) antibody, melioidosis (Burkholderia pseudomallei infection)
Extended linkage
DRB1*1601:DQA1*0102:DQB1*0502 haplotype is associated with tubeculousis risk
*1602:DQA1*0102:DQB1*0502 haplotype: graves disease, cervical cancer (human papilloma virus infection), scleroderma *1602:DQA1*05:DQB1*0301 haplotype: rheumatic heart disease, systemic sclerosis
Genetic Linkage DR16 Haplotypes Serotypes DRA DRB1 DRB5 DR16(2)-DR51 *0101 *1601 *0101 *0101 *1602 *0101 *0101 *1604 *0101 DQA1 DQB1 DRB1 DR16(2)-DQ5 (5.2, 1) *0102 *0502 *1601 HLA-A HLA-B DRB1 A2-B51(5)-DR16(2) *0201 *5101 *1601
HLA-DR16 is genetically linked to HLA-DR51 and HLA-DQ5 serotypes.
References