major histocompatibility complex, class II, DR18 Haplotypes groups DRA*01:DRB1*0302 DRA*01:DRB5*0303 Structure (See HLA-DR) Identifiers alpha *0101 Symbol(s) HLA-DRA EBI-HLA DRA*0101 Identifiers beta 1 *0302 *0303 Symbol(s) HLA-DRB1 EBI-HLA DRB5*0302 EBI-HLA DRB1*0303 Shared data Locus chr.6 6p21.31
HLA-DR18 (DR18) is a HLA-DR serotype that recognizes the DRB1*0302 and *0303 gene products. Compared to DR17 which is found at high frequency in Western Europe, DR18 is found more in SE Europe and Central Asia.
Serology + DR18 recognition of some DRB1*03 allelesderived from IMGT/HLA DRB1* DR18 DR3 DR17 Sample allele % % % size (N) 0302 66 24 3 317 0303 60 40 5
DR18 recognizes the DRB1*0302 and *0303, the thoroughness of recognition is fair, but better than DR3.
Disease associations DR18 seropositivity is associated with rheumatoid polyarthritis
DRB1*0302 is positively associated with juvenile diabetes, nuclear helicase Mi-2 autoantibodies in inflammatory inclusion body myositis.
Genetic Linkage DR18 Haplotypes Serotypes DRA DRB1 DRB3 DR18(3)-DR52 *0101 *0302 *0101 DQA1 DQB1 DRB1 D18(3)-DQ2(2.5) *0501 *0201 *0302 HLA-A HLA -B DRB1 A33-B58-DR18(3) *3301 *5801 *0302
HLA-DR18 is genetically linked to DR52 and HLA-DQ2 serotypes. These serotypes are the result of gene products from the HLA-DRB3* and HLA DQA1*0501 and HLA DQB1*0201 alleles.
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