major histocompatibility complex, class II, DR51 Haplotypes groups DRA*01:DRB5*01 DRA*01:DRB5*02 Structure (See HLA-DR) Identifiers alpha *0101 Symbol(s) HLA-DRA EBI-HLA DRA*0101 Identifiers beta 5 *01 *02 Symbol(s) HLA-DRB5 EBI-HLA DRB5*01 EBI-HLA DRB5*02 Shared data Locus chr.6 6p21.31
HLA-DR51 is a HLA-DR serotype that recognizes the antigens encoded by the minor DR locus HLA-DRB5.
DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution, having diverged from DRB1 approximately 4 million years ago.
DRB5 locus is only apparent in a small subset of DR haplotypes, and most individuals lack DRB5.
Alleles + DR52 recognition of some DRB3* allelesderived from IMGT/HLA DRB5* DR51 ? Sample allele % % size (N) 0101 >71 28 0102 >86 8 0202 >86 13
DRB5* is subdivided into two allele groups, DRB5*01 and DRB5*02. B5*01 encodes 14 alleles and 11 isoforms. B5*02 encoded 4 alleles that can generate 4 isoforms. Only 3 of these have been surveyed by serotyping. There are numerous null genes at this locus.
DRB5*01 allele group 14 Alleles: 11 proteins, 2 Nulls DR51 Serotype: *0101, *0102 Serotype unknown: *0103 to *0107, *0109, *0110 to *0113 Nulls: *0108N, *0110N
DRB5*02 allele group 4 Alleles: 4 proteins DR51 Serotype: *0202, Serotype unknown: *0203 to *0205
Associated diseases
DR51 serotype is positively associated with The following HLA-DRB5 alleles are associated with disease:
DRB5*0101:DRB1*1501 Multiple sclerosis, leprosy
DRB1 linkage HLA-DRB5 (DR51)is linked to the following HLA-DR serotypes and DRB1 allele groups.
HLA-DR2 HLA-DR15 - DRB1*15 HLA-DR16 - DRB1*16
References