major histocompatibility complex, class II, DR53 Haplotypes groups DRA*01:DRB3*01 DRA*01:DRB3*02 DRA*01:DRB3*03 Structure (See HLA-DR) Identifiers alpha *01:01 Symbol(s) HLA-DRA EBI-HLA DRA*01:01 Identifiers beta 3 *01 *02 *03 Symbol(s) HLA-DRB3 EBI-HLA DRB3*01 EBI-HLA DRB3*02 EBI-HLA DRB3*03 Shared data Locus chr.6 6p21.31 HLA-DR52 is an HLA-DR serotype that recognizes gene products of HLA-DRB3 locus. Three allele groups can produce 35 isoforms.
DRB3, DRB4, and DRB5 are minor DR beta-encoding loci, and they have been recognized as having distinct evolution, having diverged from DRB1 around 4 million years ago.
The DRB3 locus is only apparent in a small subset of DR haplotypes, and most individuals lack DRB3.
Alleles + DR52 recognition of some DRB3* allelesderived from IMGT/HLA DRB3* DR52 ? Sample allele % % size (N) 01:01 95 62 01:02 99 1 02:01 99 2 02:02 95 100 02:03 95 1 03:01 95 36
Associated diseases
DR52 serotype is positively associated with systemic sclerosis, inflammatory myopathies, inclusion body myositis,
DRB3*01 is positively associated with sarcoidosis, Grave's Disease, pulmonary sarcoidosis,
DRB3*01:01:DRB1*03:01 is linked to Lofgren's syndrome
DRB3*02:02 is also linked to Grave's disease, serum IgG antibodies to Chlamydia pneumoniae with essential hypertension, acute necrotizing encephalopathy
DRB3*03:01 is weakly associated with anticardiolipin antibodies in SLE
DRB3*03:01:DRB1*13:02 may be associated with Crohn's disease
DRB1 linkage HLA-DRB3 is linked to these HLA-DR serotypes and DRB1 allele groups:
HLA-DR3 - DRB1*03
HLA-DR5 - HLA-DR11 - DRB1*11 HLA-DR12 - DRB1*12
HLA-DR6 - HLA-DR13 - DRB1*13 HLA-DR14 - DRB1*14
Rarely HLA-DR8 - DRB1*08
HLA-DR52 - Sjögren syndrome
References