Gilhooley or Gilhooly is a surname which may refer to:

People Brenda Gilhooly (born 1964), English comedian David Gilhooly (1943–2013), American ceramic artist Frank Gilhooley (1892–1959), American baseball player Frankie Gilhooley (1924–2010), American basketball player and baseball announcer James Gilhooly (1847–1916), Irish Nationalist politician Maria Gilhooley (), stage name Marry Waterson, English singer, songwriter and visual artist Michael Gilhooley (1894–1969), Scottish footballer Patrick Gilhooley (1876–1907), Scottish footballer Ray Gilhooley (1887–1973), American racecar driver

Fictional characters The widow Gilhooley, in the Irish television series Killinaskully Thomas "Boats" Gilhooley, in the 1963 John Ford movie Donovan's Reef, played by Lee Marvin

See also Gilhoolie, a jar opener