The Roman Catholic Diocese of Santo Tomé (), is located in the city of Santo Tomé, in the province of Santa Fe, Argentina.
History On 3 July 1979, Blessed John Paul II established the Diocese of Santo Tomé from the Archdiocese of Corrientes and the Diocese of Goya.
Ordinaries Carlos Esteban Cremata (1979–1985) Alfonso Delgado Evers (1986–1994), appointed Bishop of Posadas Francisco Polti Santillán (1994–2006), appointed Bishop of Santiago del Estero Hugo Norberto Santiago (2006–2016), appointed Bishop of San Nicolás de los Arroyos) Gustavo Alejandro Montini (2016- )
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