Lézignan may refer to:
In geography: Lézignan, Hautes-Pyrénées, a commune in the Hautes-Pyrénées department, France Lézignan-Corbières, a commune in the Aude department, France Lézignan-la-Cèbe, a commune in the Hérault department, France
In other uses: Lézignan Sangliers, a rugby league football club based in Lézignan-Corbières