Spilsbury is a surname. Notable people with that surname may include:
Albert Spilsbury (1894–1959), English footballer Benjamin Spilsbury (1864–1938), English footballer Sir Bernard Spilsbury (1877–1947), British pathologist George Green Spilsbury (1786–1857), British surgeon John Spilsbury (Baptist minister) (1593–), English cobbler and Particular Baptist minister John Spilsbury (cartographer) (1739–1769), British mapmaker and engraver who invented the jigsaw puzzle John Spilsbury (cricketer) (born 1933), English cricketer Jonathan Spilsbury (–1812), English engraver Klinton Spilsbury (born 1951), American actor Maria Spilsbury (1776–1820), British artist Thomas Spilsbury (1874–1947), English footballer Tom Spilsbury (born 1976), British writer, magazine editor and journalist