Fotopoulos () or Photopoulos (sometimes for female persons it becomes: Fotopoulou or Photopoulou) is a Greek surname. Notable people with the surname include:
Danielle Fotopoulos (born 1976), soccer player, US women's national soccer team George Fotopoulos, former head coach of the LSU women's soccer team Helen Fotopulos, Montreal city councillor James Fotopoulos (born 1976), American independent filmmaker Konstantinos Fotopoulos (born 1959), Greek convicted murderer on death row in Florida Mimis Fotopoulos (1913–1986), Greek actor Takis Fotopoulos (born 1940), Greek political writer and editor Vassilis Photopoulos (1934–2007), Greek painter and film director