James Knox (1914–1983) was the Catholic archbishop of Melbourne, 1967–74.

James or Jim Knox may also refer to:

James Hall Mason Knox (1824–1903), Presbyterian, educator, president of Lafayette College James Knox (cyclist) (born 1995), British cyclist James Knox (Illinois politician) (1807–1876), U.S. Representative from Illinois James Knox (Montana politician) (born 1965), Republican member of the Montana Legislature and politician James Knox (British politician) (1790–1856), member of parliament for Dungannon James Meldrum Knox (1878–1918), British Army officer James Knox, lead singer of The Waltones Jim Knox (1919–1991), New Zealand trade unionist and politician Jim Knox (American football), Fox Sports American football commentator, see 2000 Oklahoma Sooners football team Jim Knox (ice hockey), Canadian ice hockey goaltender, 1966 Memorial Cup champion, brother of Swede Knox James Knox Polk (1795–1849), 11th U.S. president