SPAP may refer to:
Piraeus, Athens and Peloponnese Railways (Siderodromi Pireos Athinon Peloponisou), a meter-gauge railway network in southern Greece Samodzielny Pododdział Antyterrorystyczny Policji or Independent Counter-terrorism Police Subdivision, independent anti-terrorist police subunits of the Polish police Seaport-Airport Road, a proposed highway to Cochin International Airport, Kerala, India Secure Password Authentication Protocol Shiva Password Authentication Protocol Socialist Popular Alliance Party, Egypt Sodium-proton antiporter State Prescription Assistance Program, a social program prescription assistance offered in U.S. states as part of Medicaid Systolic pulmonary artery pressure (sPAP); see pulmonary hypertension