Isotta may refer to:
the Italian form of the name Iseult Isotta degli Atti (died 1474), an Italian regent Isotta Brembati (died 1586), Italian poet and countess Isotta Fraschini, Italian luxury car manufacturer Isotta Gervasi (1889–1967), Italian medical doctor Isotta Nogarola (1418–1466), Italian writer and humanist Isotta Ingrid Rossellini (born 1952), Italian writer and academic Isotta Brothers (19th century), Italian hoteliers Paolo Isotta (1950–2021), Italian musicologist