Route 380 or Highway 380 may refer to:
Canada New Brunswick Route 380 Newfoundland and Labrador Route 380
Japan Japan National Route 380
United States Interstate 380 U.S. Route 380 Arizona State Route 380 (cancelled proposal) Arkansas Highway 380 Georgia State Route 380 Louisiana Highway 380 Maryland Route 380 New York State Route 380 (former) Ohio State Route 380 Oregon Route 380 Pennsylvania Route 380 Puerto Rico Highway 380 Tennessee State Route 380